43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. Looks like you're using new Reddit on an old browser. With the CAGR of X.X%, this market is estimated to reach USD XX million in 2026. I'm sure I'm going to miss more information I wanted to put in here that might be relevant to new users so feel free to ask me anything and I'll get back to you and update this as soon as I can. The Memantine market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. Above 100mg and you'll likely not be moving from your bed/couch very often, although it is possible. It feels almost like you can will yourself in and out of consciousness at that dose. Never heard of this drug before. When in doubt, DON'T. 1. Both the research [18] and anecdotal reports [19] recount as much. Insufflation works, has a slightly faster onset but is fairly painful. Sweet write up, it sounds like an interesting drug worth experiencing. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. One interesting memantine side effect includes higher libido. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … A sub for discussing all uses of Memantine, from therapeutic to recreational. If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. You can take memantine either before or after meals. If you over shoot it, it's a very long time to endure it. I have a few questions regarding its effects however. If it isn't apparent guys, I have a lot of spare time. There are over-the-counter medications available to acidify the urine too; for example, pills containing methionine, which is used to prevent bladder infections.' This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in … Score with placebo (median) Mean improvement in change score between memantine and placebo. Memantine Dosage. The results have shown a significant difference in the behavior and attention deficit between the two groups treated with memantine and placebo during 6 weeks (p < 0.001). However, the drug does not cure Alzheimer’s. Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. And for the most part I'm perfectly functional cognivitely. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. 279, 280 Via inhibition of NMDA receptors, memantine prevents the mitochondrial swelling, increases oxidative stress, and decreases … Make sure you follow the RULES. Preface. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. The mean age of patients who were receiving memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years, respectively. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. However my memory lapses happen every 2 weeks or so and only for a short period. Adding the Alzheimer drug memantine to a selective serotonin reuptake inhibitor (SSRI) may improve depressive symptoms, as well as apathy, anxiety, and cognitive function, in older patients. Nice report. I'll explain how some of these play a role in the subjective experience down further. Continuous outcomes. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Get your prescription refilled before you run out of medicine completely. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Then memantine is pulled into the channel to its binding site. Take one dose every day, at the same time of day each day. Is it possible to hole on? We promote harm reduction and fight against the drugs stigma. Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. With that being said, I don't think memantine would be an enjoyable experience for everyone. Results were inconclusive because of studies with poor levels of … Whereas on DXM, it might be too hard to try to play a game. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. That way, memantine is eliminated 7-10 times faster. In 2003, the FDA approved Memantine for the treatment of both severe and moderate Alzheimer’s disease. I could see some thereputic use in this because of it's functionality and long half life. Visually fairly similar to ketamine, but more controllable. Just remember that there is no 100% safe drug use. This will … 30mg seems to be barely a threshold dose. I have just awoken at 90+ hours, and I think I'm finally pretty much back to baseline. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. Memantine seems less debilitating than that of Ketamine or DXM. Memantine is used for treatment of moderate-to-severe stage of AD. User Reviews for Memantine. Reddit; Wechat; To the Editor, We read with interest the papers by Brenner 1 and Cimolai 2 regarding the therapeutic potential of memantine for coronavirus disease 2019 (COVID‐19). Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. How long do the effects last? Memantine acts as a mild stimulant, raising heart rate and with a sense of weightlessness it feels encouraging to be physically active at low doses. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of … The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Memantine is a prescription drug that is also known by the brand name Namenda. The memantine dosage will differ based on the use case. I'm clumsy and stumbling a bit, but I'm able to use a keyboard and phone just fine. Treatment should only be continued if beneficial effects are seen. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. Furthermore, memantine caused short-term worsening of neurologic symptoms in MS, thereby exacerbating the cognitive deficits [ 41 ]. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. Please comment back on what your experience was like at that dose though. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. Thanks! Auditory effects are negligible on Memantine, an enhanced appreciation for music is apparent, but no more than a slight ringing in the ears will be noticed (Memantine has shown efficacy in treatment for tinnitus so who knows what's going on there). Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Sourcing drugs is NOT allowed here! Your doctor will need to check your progress while you are using memantine. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. It has a pretty clear anxiolytic effect on me. Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. Cheers man, I'll put it to good use. Keep the liquid medicine bottle tightly closed with the cap provided. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. TL;DR: Memantine has a high potential for recreational use. How much does it help? A recent meta-analysis found substantial benefits of memantine in treating obsessive-compulsive disorder. I've come to find that most chemicals go: I started taking memantine a few months ago, and have experimented a few times with higher recreational doses. 85mg Memantine Trip Report from January 2019 (edited, repost) Experience Report. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. It is taken by mouth. I haven't pushed the limits enough to definitively say it exists. Although there is moderate-certainty evidence that fewer people taking memantine experience agitation as an adverse event: RR 0.81 (95% CI 0.66 to 0.99) (25 fewer people per 1000, 95% CI 1 to 44 fewer), there is also moderate-certainty evidence, from three additional studies, suggesting that memantine is not beneficial as a treatment for agitation (e.g. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. This is a risk reduction resource. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. The review covers memantine studies in postherpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid‐refractory pain and fibromyalgia. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. I'm super happy I'm not the only one around here using it like this. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Functional enough to play games like Overwatch and keep up with it without any struggle. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. The half-life really makes this unsuited for recreational use imo. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. You need to leave yourself at least 12 hours before you want to sleep before dosing. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. New comments cannot be posted and votes cannot be cast. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. 2019 One meta-analysis showed that there was a significant improvement in cognitive function in AD patients who took memantine. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. I feel very clear-headed on memantine. Common side effects … I want to bring it to light as the amazing drug it is. Memantine 20 mg compared to placebo for mild AD (MMSE 20‐23) observed case (OC) ‐ six‐month studies for dementia. Dr Andrade takes a closer look at the methods the authors used and the studies they included to weigh the merits of their conclusions. Ketamine: Much less sedating. The visuals and euphoria become much more intense and interesting after weed is smoked. The high is quite non-intrusive though so it's really best used for a background high I think. The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. ... T+03:00 Texted my friend for a bit, browsed Reddit, watched YouTube. 278 Memantine blocks the extensive activity of NMDA receptors but does not accumulate to interfere with normal synaptic transmission, and hence no disruption of normal physiological activity. In this study, we evaluated whether a combination of memantine with melatonin, administered for 32 days in drinking water, was more effective than either drug alone with respect to Aβ aggregates, neuroinflammation and cognition in the double transgenic APP/PS1 (5xFAD) mouse model of AD. Press question mark to learn the rest of the keyboard shortcuts. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. That being said, Memantine is a beautiful drug. I'm on 20mg daily for mood stabilisation. A short intro to Memantine. Memantine was not effective at reducing cognitive deficits, and patients who tried memantine had more adverse effects such as fatigue . I tried memantine a few times and enjoyed it enough, but it’s a weird one, isn’t it? It is a long acting NMDA receptor antagonist that binds to an open channel binding site. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. 3 McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J. Memantine as a treatment for dementia, Dementia and Cognitive Improvement Group. Due to its antagonism of the N-methyl-d-aspartate (NMDA) receptor, which has been shown to block rewarding and reinforcing effects of morphine, memantine has been investigated for potential utilization in … From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. Memantine is an uncompetitive NMDA receptor antagonist, and subjectively feels somewhere between Ketamine & DXM (perhaps closer to one of PCP analogues, but I can't comment on their subjective effects) with a longer duration than either. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Memantine is commonly used for the treatment of moderate-to-severe Alzheimer's disease. It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. Super Sour Ketamine is what I would describe the taste as. Do you have any previous experience with dissociatives, and if so how do they compare? Psychonautwiki founder here, you did an amazing job on the mementine article dude. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. the headspace has much less "static" noise, even compared to being sober. Store memantine at room temperature away from moisture and heat. Great write up, thanks for the info! You will be given a small dose when you first start treatment. Can you elaborate more on how it helped your depression? It's clean feeling, compared to DXM. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. Sorry, this post was deleted by the person who originally posted it. I can't compare it to MXE, and it's been a few months since I last had ketamine but I'll do the best I can to explain. 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